Study on Pharmacological Key Problems of Druggability Evaluation for Novel Chinese Materia Medica
10.11842/wst.2017.03.008
- VernacularTitle:中药新药成药性评价关键药理学问题探讨
- Author:
Guanhua DU
;
Li ZHANG
- Keywords:
Novel Chinese materia medica;
druggability evaluation;
pharmacology;
evaluation technology
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(3):432-438
- CountryChina
- Language:Chinese
-
Abstract:
The research and development (R & D) of novel Chinese materia medica (CMM) have made a great progress in recent years.But problems still exist in druggability evaluation of novel CMM,such as uncertain evaluation content and lack of key technology.Druggability evaluation is the key to the success or failure for R & D of novel CMM.Observation on the effect and safety of novel CMM is the core of druggability evaluation.The important pharmacological problems include the choice of evaluation indicator,clinical indication,analysis of material basis,investigation of mechanism,research on pharmacokinetics and safety evaluation.Modem technologies should be used in druggability evaluation.We should have a correct understanding of the concept of novel CMM.The grasp of the meaning of novel drugs and the essence of CMM theory will be helpful for R & D of novel CMM.
