Drug Quality Representation Analysis of Preparations of Aurea Helianthus based on Anti-myocardial Ischemia Effect
10.11842/wst.2017.03.022
- VernacularTitle:基于抗心肌缺血作用的金花葵制备物药物质量表征分析
- Author:
Li TAN
;
Jing KONG
;
Duo FENG
;
Lu LIU
;
Shan LV
;
Yuanyuan ZHANG
;
Renbing SHI
- Keywords:
Preparation of Aurea Helianthus;
anti-myocardial ischemia;
quality characteristics;
pharmacy-efficacy correlation analysis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(3):522-528
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to select the best preparation form of Aurea Helianthus in order to provide a scientific basis for research and development of anti-myocardial ischemia drugs.The content of effective index components of preparation of Aurea Helianthus was detected using HPLC-PDA.Acute myocardial ischemia rat model introduced by injecting pituitrin was used to investigate the effect of anti-myocardial ischemia.The quality of preparation from Aurea Helianthus was characterized based on pharmacy and efficacy.And the characterized results were given correlation analysis.The results showed that the HPLC method for quantitative determination was verified by methodology.The average recoveries were in the range of 97.04％-102.44％.All three preparations of Aurea Helianthus had the efficacy of anti-myocardial ischemia in varying degrees.The enrichment had the highest effect with lowest extraction rate and the lowest dosage,which was the best form in medicinal-preparation application of Aurea Helianthus.It was concluded that the content of related drug components was higher with unique proportion in enrichment of Aurea Helianthus which was prepared based on drug system proved a high quality medicine.Therefore,the key to the improvement of efficacy was to explore the fittest proportion and improve the content of related pharmaceutical ingredients pertinently according to drug system.
