A Progress on ADME and the Toxicity of Fructus Psoralea
10.11842/wst.2017.02.014
- VernacularTitle:补骨脂ADME及其相关毒性的研究进展
- Author:
Yu WANG
;
Jiaming JIANG
;
Siyuan KONG
;
Hongsheng TAN
;
Lianbo XIAO
;
Hong ZHANG
- Keywords:
Fructus psoralea;
main components;
ADME;
clinical side effects;
toxicity
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(2):276-281
- CountryChina
- Language:Chinese
-
Abstract:
Fructus psoralea is a tonic traditional Chinese herb commonly used in clinic.The chemical constituents of Fructus psoralea are complicated,mainly containing coumarins,flavonoids and monoterpene phenols with various pharmacological effects.Since the increasing number of reports on the toxicity of Fructus psoralea in clinic,the side effects including toxicity on the liver and kidney,as well as skin allergies have gradually attracted attention.The toxicity of Fructus psoralea is produced from ADME (absorption,distribution,metabolism and excretion) in vivo.In this paper,we collected and clarified the studies of ADME of Fructus psoralea in vivo,and summarized recent adverse clinical events and research over its toxicity.We propose to make a thorough study on the toxic material basis of Fructus psoralea and the toxicological mechanism of its extraction,fractions and compounds.The review provided a possible reference and the direction of research for the safe clinical use of Fructus psoralea.