"Study on ""Different Diseases of the Same Syndrome"" Damp-heat Syndrome based on Metabonomics"
10.11842/wst.2017.03.003
- VernacularTitle:基于代谢组学方法的湿热证“异病同证”研究
- Author:
Chang LIU
;
Xiaojun GOU
;
Di HUANG
;
Chaoqun ZHAO
;
Ping LIU
;
Yongping MU
;
Jianmei CAO
;
Hua ZHANG
- Keywords:
Traditional Chinese medicine syndrome;
metabonomics;
damp-heat syndrome;
different diseases of the same syndrome;
material basis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(3):392-407
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to reveal the material basis on different diseases of the same syndrome damp-heat syndrome from the level of metabonomics.The typical damp-heat syndrome patients diagnosed as chronic viral hepatitis B,non-alcoholic fatty liver disease,or chronic glomerulonephritis were included,with 30 cases in each disease.There were 30 healthy volunteers in the control group.The serum samples were detected by UPLC-QTOFMS and GC-TOFMS.And then,the results were analyzed by variance analysis in order to find out the generality and specificity of metabolic material in three different diseases with damp-heat syndrome.The results showed that through comparisons of different diseases with damp-heat syndrome,as well as the healthy group as control,it was revealed that inosine,uridine,aspartic acid,oleic acid glyceride and lactate were the same substances of three diseases of damp-heat syndrome.It was concluded that based on metabonomics,as for three different diseases with damp-heat syndrome,there were different substances among different diseases,but common substances related to damp-heat syndrome.Thus,it provided objective evidences for the theory of different diseases of the same syndrome in traditional Chinese medicine (TCM) from the level of metabonomics.
