Drug Quality Characterization Consideration of Preparations of Oil Tea Camellia Defatted Cake based on Antithrombotic Effect
10.11842/wst.2017.03.021
- VernacularTitle:基于抗血栓作用的油茶枯饼药物制备物质量表征分析
- Author:
Yali WANG
;
Lifeng SHEN
;
Linfu LI
;
Qiuhong WU
;
Dongbo LU
;
Wenxia LI
;
Renbing SHI
- Keywords:
Oil tea camellia defatted cake;
drug system;
quality consideration;
pharmacy-efficacy
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(3):516-521
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to select the best preparation form of medicinal in camellia cake,based on the optimal antithrombotic agents in oil tea camellia defatted cake to establish the foundation of research.The content of effective index component of the oil tea camellia defatted cake preparation was detected by HPLC-PDA.The quality of medicinal preparation from oil tea camellia defatted cake was characterized based on the content,relative quantity,relative ratio of content,yield rate and antithrombotic effect.The results showed that the effect of antithrombotic of three medicinal preparations from oil tea camellia defatted cake was listed in the following descending order of enrichment,ethanol extract,and water extract.The enrichment was the best preparation form of medicinal in oil tea camellia defatted cake preparation with the highest content of effective index components,the lowest extract rate and the lowest dosage.But it had the best effect of antithrombotic.It was concluded that the significant improvement of efficacy was due to the increase of the content of the components in the preparation and the rationality of the proportion.At the same time,analysis of component quality based on basic composition of drug system through the consideration of effective components of type and quantity,composition and other quality factors can further guide the preparation of drugs.
