Different expression patterns of β-catenin and its correlation with clinicopathological facters in colorectal cancer
10.13315/j.cnki.cjcep.2017.06.002
- VernacularTitle:β-catenin不同表达模式与结直肠癌临床病理因素的关系
- Author:
Wen JIN
;
Shunhua CHEN
;
Yu YIN
;
Cong ZHANG
;
Liyu CAO
- Keywords:
colorectal neoplasms;
β-catenin;
expression patterns;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(6):596-600,605
- CountryChina
- Language:Chinese
-
Abstract:
To observe different expression patterns of β-catenin and its clinical significance in colorectal cancer (CRC).Methods A total of 181 cases of CRC tissues and 30 cases of normal colorectal tissue were investigated by immunohistochemistry for the expression of β-catenin.Results The expression rate of β-catenin was 56.9％ (103/181) in CRC,and higher than that in normal colorectal tissue (P ＜ 0.05).The overexpression of nuclear β-catenin was significantly correlated with histological differentiation,lymph node metastasis and Dukes' stage in CRC (P ＜ 0.05),and no relationship with other pathological parameters,such as age,gender and the depth of infiltration.The incomplete membranous expression of β-catenin was significantly correlated with histological differentiation,the depth of infiltration,lymph node metastasis and Dukes' stage in CRC (P ＜ 0.05).The high expression of nuclear β-catenin related to histological differentiation and Dukes' stage in CRC (P ＜ 0.05).In the follow-up data of 82 cases of CRC,the expression of nuclear β-catenin was associated with poor prognosis,and the 5-year survival rate was significantly lower than that of self-control groups (P ＜ 0.05).Conclusion β-catenin plays important roles in colorectal carcinogenesis.Abnormal expression of β-catenin was related to the aggressive progression of CRC and may be helpful for evaluating the prognosis of patients with CRC.β-catenin is expected to become a new target for diagnosis and treatment of CRC in future.
