1H-MRS research of cerebral metabolic changes in patients with type 2 diabetes mellitus
10.3969/j.issn.1002-1671.2017.06.002
- VernacularTitle:1H-MRS在2型糖尿病患者脑代谢改变中的应用
- Author:
Quan LI
;
Li ZHANG
;
Jia BIAN
;
Chengzhou ZHANG
;
Xiao TANG
- Keywords:
type 2 diabetes mellitus;
proton magnetic resonance spectroscopy;
brain metabolism
- From:
Journal of Practical Radiology
2017;33(6):524-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the efficacy of glucose-loweringtreatment by proton magnetic resonance spectroscopy (1H-MRS).Methods Bilateral frontal lobes of 45 male patients with type 2 diabetes mellitus (T2DM) underwent 1 H-MRS separately bythe time it was first diagnosed.Among them,30 were treated with insulin,15 were rejected.The bilateral frontal lobes of all patients were re-examined with 1 H-MRS after 6 months.The ratios of metabolites in the frontal lobe were recorded and compared,and observing whether the lactate(Lac) peak appeared or not.Results Significantly higher values of the N-acetylaspartate (NAA)/creatine (Cr)ratio and NAA/choline (Cho) ratio after 6 months (2.414 2± 0.206 6 and 2.244 2±0.341 5) were found in bilateral frontal lobes compared with pre-therapy (1.905 3±0.135 7 and 1.906 0±0.322 1)(P＜0.05).Significantly lower values of the NAA/Cr ratio and NAA/Cho ratio in the refuse treatment group(1.504 2 ± 0.262 4 and 1.510 0± 0.220 8) were found in bilateral frontal lobes compared with pre therapy (1.960 0±0.175 0 and 1.880 8±0.297 0)(P＜0.05).Lac peak was not detected in the all experiments.Conclusion 1 H-MRS provides valuable information in the assessment and evaluation of clinical efficacy and prognosis of T2DM by detecting the changes of brain metabolism.
