"Relationship between diabetic retinopathy ""metabolic memory"" and oxidative stress"
10.3760/cma.j.issn.1005-1015.2017.03.030
- VernacularTitle:糖尿病视网膜病变“代谢记忆”与氧化应激的相关性研究现状
- Author:
Wei GAO
;
Chunxia LI
- Keywords:
Diabetic retinopathy/physiopathology;
Oxidative stress;
Endoplasmic reticulum stress;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2017;33(3):327-330
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic memory means if the hyperglycemia can't be controlled at early stage of diabetes,chronic complications such as diabetic retinopathy (DR) will continue to develop even if the blood glucose level maintains normal level at later stage.Oxidative stress plays an important role in the metabolic memory of DR,which interacts with the nitrative stress,advanced glycation end products,genetic modification and endoplasmic reticulum stress in the pathogenesis of DR.Further elucidation of the relationship between oxidative stress and metabolic memory of DR can open the way for the discovery of novel therapeutic targets to prevent DR progression.
