Correlation of serum S100B protein and human anti-brain tissue antibody levels with cognitive function in patients with Alzheimer's disease
10.3969/j.issn.1000-6729.2017.07.004
- VernacularTitle:阿尔茨海默病患者血清S100B蛋白和抗脑抗体浓度与认知功能关系
- Author:
Junchao HUANG
;
Lan SHANG
;
Jianxin ZHANG
;
Zhiren WANG
;
Yong ZHANG
;
Shuping TAN
;
Yuechan WANG
;
Fude YANG
;
Dongfeng ZHOU
;
Yunlong TAN
- Keywords:
Alzheimer's disease (AD);
S100B protein;
anti-brain anti-body (ABAb);
cognitive function
- From:
Chinese Mental Health Journal
2017;31(7):523-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the roles of S100B protein and anti-brain antibody (ABAb) in the pathophysiology of Alzheimer's disease (AD) by analyzing the changes of the serum levels of S100B and ABAb and the relationships of the measures with cognition deficits in patients with AD.Methods:In this study,32 patients with AD(AD group) and 40 age-matched volunteers without cognitive impairment(control group) were enrolled.The diagnosis was made according to the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition (DSM-Ⅳ).The mental and social functional conditions were assessed with the Mini-Mental State Examination (MMSE) and Activity of Daily Living Scale(ADL),the cognitive function of patients was evaluated with the Alzheimer's Disease Assessment Scale-cognitive subscale(ADAS-Cog).The serum S100B proteinand ABAb levels were examined by enzyme-linked immuno sorbent assay(ELISA).Results:The serum S100B protein[(0.66 ± 0.17) μg/L vs.(0.30 ± 0.04)μg/L] and ABAb [(1.93 ± 0.95) U/L vs.(1.31 ± 0.25) U/L] levels were higher in AD patients than in the controls (Ps ＜ 0.01).In AD patients,the serum S 100B protein markedly negatively correlated with the scores of the MMSE(r =-0.66),while positively correlated with ADL and ADAS-Cog(r =0.57,r =0.53)(Ps ＜ 0.005).ABAb levels negatively correlated with the scores of the MMSE(r =-0.57),while positively correlated with ADL and ADAS-Cog(r =0.52,r =0.34)(Ps ＜0.05).The serum S100B protein levels were positively related to ABAb levels in AD group(r =0.51.P ＜0.005),but not in control group(r =0.076,P =0.654).Conclusions:It suggests that the serum levels of S100B protein and ABAb are related with cognitive function in patients with Alzheimer's disease,and S100B protein and ABAb might play key roles in mechanism of Alzheimer's disease.
