Molecular Motor Proteins of the Kinesin Superfamily Proteins (KIFs): Structure, Cargo and Disease.
- Author:
Dae Hyun SEOG
1
;
Dae Ho LEE
;
Sang Kyoung LEE
Author Information
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords: Kinesin; Molecular Motors; Adaptor Proteins; Microtubules
- MeSH: Adenosine Triphosphate/metabolism; Alzheimer Disease/metabolism; Animals; Biological Transport; Cytoplasm/metabolism; Diabetes Mellitus/metabolism; Human; Kinesin/*chemistry/*metabolism; Mice; Microtubule-Associated Proteins/chemistry; Microtubules/metabolism; Models, Biological; Neurons/metabolism; Protein Binding; Support, Non-U.S. Gov't
- From:Journal of Korean Medical Science 2004;19(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: Intracellular organelle transport is essential for morphogenesis and functioning of the cell. Kinesins and kinesin-related proteins make up a large superfamily of molecular motors that transport cargoes such as vesicles, organelles (e.g. mitochondria, peroxisomes, lysosomes), protein complexes (e.g. elements of the cytoskeleton, virus particles), and mRNAs in a microtubule- and ATP-dependent manner in neuronal and non-neuronal cells. Until now, more than 45 kinesin superfamily proteins (KIFs) have been identified in the mouse and human genomes. Elucidating the transport pathways mediated by kinesins, the identities of the cargoes moved, and the nature of the proteins that link kinesin motors to cargoes are areas of intense investigation. This review focuses on the structure, the binding partners of kinesins and kinesin-based human diseases.
