Relationship between level of plasma ammonia,and changes of serum alpha-fetoprotein,cholinesterase,liver fibrosis index in liver cirrhosis patients with hepatocellular carcinoma in reference to Child-Pugh grades
10.3969/j.issn.1000-484X.2017.08.018
- VernacularTitle:肝硬化伴肝癌患者血氨、甲胎蛋白、胆碱酯酶、肝纤维化指标与Child-Pugh分级的相关性
- Author:
Feibo GUO
- Keywords:
Liver cirrhosis;
Hepatocellular carcinoma;
Alpha-fetoprotein;
Cholinesterase;
Plasma ammonia;
Liver fibrosis;
Child-Pugh grades
- From:
Chinese Journal of Immunology
2017;33(8):1209-1212,1217
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the level of plasma ammonia(NH3),and the changes of serum alpha-fetoprotein(AFP),cholinesterase(ChE),liver fibrosis index in liver cirrhosis patients with hepatocellular carcinoma(LC-HCC)in reference to Child-pugh grades.Methods: A total of 58 patients with LC and HCC(LC-HCC group),76 patients with LC(LC group)and 60 cases of healthy volunteers(HC group)were collected.Serum AFP were detected by electrochemiluminescence,serum Hyaluronic acid(HA),laminin(LN),type Ⅳ collagen(Ⅳ-C) were detected by chemilu minescence immunoassay,serum ChE were detected by S-Butyrylthiocholine iodide,NH3 was continuously monitored.The levels of AFP,ChE,NH3 and liver fibrosis indexes(HA,LN,Ⅳ-C) among the LC-HCC group,LC group and HC group,different Child-Pugh grades in LC-HCC group were compared.Results: The serum levels of NH3,AFP,HA,LN,Ⅳ-C in LC-HCC group were significantly higher than that in LC and HC group,and ChE levels were significantly reduced,differences between LC group and HC group were statistically significant(P<0.05).With the increase of Child-Pugh grades,the serum levels of NH3,AFP,HA,LN,Ⅳ-C in LC-HCC group were gradually increased but the ChE gradually decreased,the differences were statistically significant(P<0.05).Serum levels of ChE in patients with LC-HCC were significant negatively correlated with Child-Pugh grades,and AFP,NH3,HA,LN,Ⅳ-C were significant positive correlated with Child-Pugh grades(P<0.05).Serum levels of ChE in patients with LC-HCC were significant negatively correlated with LN,Ⅳ-C and HA,while the levels of AFP,NH3 were significant positive correlated with LN,Ⅳ-C and HA(P<0.05).Conclusion: The serum levels of AFP,ChE and NH3 in patients with LC and HCC are significant abnormalities;they are significant positive correlated with Child-Pugh grades;the detection of the these indicators is valuable to non-invasive diagnosis for patients with LC and HCC.
