Pathogens resulting in acute exacerbation of chronic obstructive pulmonary disease in patients in Ordos area
10.3969/j.issn.1671-9638.2017.08.008
- VernacularTitle:鄂尔多斯地区导致患者慢性阻塞性肺疾病急性加重的病原菌研究
- Author:
Yu GUO
;
Lianshen HE
;
Dawei JIANG
;
Zhifang ZHANG
- Keywords:
chronic obstructive pulmonary disease;
quality of life;
pathogen;
antimicrobial susceptibility testing
- From:
Chinese Journal of Infection Control
2017;16(8):726-729
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the distribution and antimicrobial resistance of pathogens isolated from patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in Ordos area,so as to provide guidance for rational antimicrobial use.Methods Sputum culture and antimicrobial susceptibility testing results of 372 patients with AECOPD in Ordos area in 2013-2015 were analyzed,and the quality of life before acute exacerbation was assessed.Results A total of 296 strains of pathogens were isolated from 372 patients,252(85.14%)of which were gram-negative bacteria,the major were Pseudomonas aeruginosa(n=58,19.59%),Klebsiella pneumoniae(n=51,17.23%),Acinetobacter baumannii(n=50,16.89%),Stenotrophomonas maltophilia(n=22,7.43%),Escherichia coli(n=19,6.42%),and Enterobacter cloacae(n=16,5.41%);27(9.12%)were fungi,the major was Candida albicans(n=19,6.42%);17(5.74%)were gram-positive bacteria,the predominant species was Staphylococcus aureus.Patients with CAT(COPD assement test)score≥10 had higher proportion of isolating Pseudomonas aeruginosa and Acinetobacter baumannii than those with CAT score<10.Conclusion The main pathogens from patients with AECOPD are gram-negative strains,CAT score prior to exacerbation may be related to the emergence of pathogens at AECOPD.
