Gray matter changes in patients with rheumatoid arthritis:a voxel-based morphometric study
10.3969/j.issn.1002-1671.2017.06.004
- VernacularTitle:基于体素的形态测量学方法对慢性类风湿关节炎患者脑灰质的MR研究
- Author:
Yongku DU
;
Jian WANG
;
Lei XU
;
Huani ZHAO
;
Yilin WANG
;
Jianhua JI
;
Zihan ZHOU
;
Chao LI
;
Xiaochun QU
;
Junle YANG
- Keywords:
rheumatoid arthritis;
gray matter;
voxel-based morphometry;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2017;33(6):532-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the gray matter in patients with rheumatoid arthritis (RA) based on the voxel based morphometry (VBM).Methods 35 patients with RA and 30 healthy volunteers with age,sex and education level matched performed a high-resolution 3D-T1-weighted whole brain structural scan by GE Signa HDxt 1.5T MRI scanner.The high resolution T1WI images were preprocessed by the VBM 12 implemented in the SPM 12 software to display the gray matter structures of the RA patients and the healthy volunteers.T test was used to compare the morphological changes of gray matter between the RA patients and the volunteers.Results The gray matter volume gray matter volume in the right lentiform nucleus,left frontal lobe and left cerebellum posterior lobe significantly decreased in RA patients,and their gray matter volume had no correlation with the clinical indications.The increase of gray matter volume was not found in the RA patients.Conclusion RA patients show decreased gray matter volume in several cerebral regions,which suggests that RA can lead to the brain structural abnormalities.VBM can provide an objective imaging evidence to evaluate the cerebral morphological abnormalities of RA.
