Progress of PML post-translational modifications in tumor cells
10.3969/j.issn.1000-4718.2017.08.031
- VernacularTitle:PML翻译后修饰在肿瘤细胞中的研究进展
- Author:
Qian HUANG
;
Xueping LIN
;
Weiwei PAN
;
Shengbing LIU
- Keywords:
PML protein;
PML nuclear bodies;
SUMOylation;
Phosphorylation
- From:
Chinese Journal of Pathophysiology
2017;33(8):1532-1536
- CountryChina
- Language:Chinese
-
Abstract:
The promyelocytic leukemia (PML) protein is an important part of the PML nuclear bodies (PML-NBs) structure.PML protein is crucial for the assembly of PML-NBs and recruits more than 30 different proteins, including DAXX, ATRX, and small ubiquitin-like molecules involving SUMO to the PML-NBs region.Increased evidence has emerged that a number of different proteins is involved in regulating PML activities by post-translational modifications, such as SUMO modification, ubiquitination and phosphorylation.Here, we review recent studies on the combination of PML and different proteins in the process of apoptosis, replicative senescence and DNA damage response.
