A Clinical Study on the Anti-Hypertensive Effect of Cilazapril in Mild to Moderate Hypertensive Patients.
10.4070/kcj.1991.21.4.764
- Author:
Dae Suk HAN
;
Jyu Hun CHOI
;
Wu Chang CHOI
;
Sung Kyu HA
;
Ho Yung LEE
;
Woong Ku LEE
- Publication Type:Original Article
- Keywords:
Cilazapril;
Hypertension
- MeSH:
Alkaline Phosphatase;
Antihypertensive Agents;
Blood Cell Count;
Blood Glucose;
Blood Pressure;
Body Weight;
Chemistry;
Cholesterol;
Cilazapril*;
Cough;
Dizziness;
Dyspepsia;
Electrocardiography;
Electrolytes;
Headache;
Heart Rate;
Humans;
Hypertension;
Hypotension, Orthostatic;
Oxidoreductases;
Peptidyl-Dipeptidase A;
Platelet Count;
Urinalysis
- From:Korean Circulation Journal
1991;21(4):764-773
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to investigate the efficacy and safety of oral cilazapril, a new angiotensin converting enzyme inhibitor, on essential hypertension, a single daily dose of 2.5 to 5.0mg cilazapril was administered in 30 hypertensive patients with diastolic blood pressure in the range of 95??15mmHg while off all other anti-hypertensive agents for 10 weeks. Blood pressure and heart rate were measured every 2 weeks. The complete blood count with platelet count, blood chemistry by SMA-12 including lactic dehydrogenase and serum electrolytes, and urinalysis were performed at 4th and 10th week of therapy. The electrocardiography was performed at the beginning and the end of treatment period. Any kinds of side effects were actively questioned by the examining physicians. The following results were obtained : 1) The mean age was 49.2 years, and the ratio of male-to-female was 1 : 1.3. 2) Blood pressure started to fall significantly within 2 weeks of treatment with cliazpril 2.5mg(M+/-S.E., 15.4+/-17.4mmHg vs 138.5+/-23.3, 100.3+/-6.2 vs 89.4+/-6.6, p<0.05), and after 6 weeks of treatment with a mean dosage of 2.84mg. diastolic blood pressure of all subjects was maintained below 90mmHg throughout the rest of trial. 3) Pulse rate or body weight were not significantly changed during the entire treatment period(69.3+/-6.0/min vs 10th week : 69.0+/-7.7, 64.7+/-7.4kg vs 63.6+/-6.7, p>0.05). 4) There were no significant changes in blood chemistry including blood sugar, cholesterol and electrolytes, except mild changes of serum creativine and alkaline phosphatase values. 5) Hematologic findings, urinalysis and electrocardiographic findings remained unchanged. 6)Side effects were mostly mild in nature without potentially serious episodes(dry cough : 20%, indigestion, headache, dizziness, in order), but there was 1 cases in whom the dosage was redyced due to postural hypotension. From the above results, cilazapril with the dosage of 2.5 to 5.0mg was effectvie and well tolerated in essential hypertensive patients with diastolic blood pressure of 95 to 115mmHg, and cilazapril seems to be appropriate for monotherapy of mild to moderate hypertensive patients.
