Hypotensive Efficacy and Safety of Ramipril on the Patients with Essential Hypertension.
10.4070/kcj.1991.21.4.774
- Author:
Won Sang YOO
;
Sung Woon KWON
;
Chang Young LIM
;
Sang Hyun PARK
;
Suck Koo CHOI
;
Dong Chul LEE
- Publication Type:Original Article
- Keywords:
Ramipril;
Essential hypertension
- MeSH:
Asthenia;
Blood Pressure;
Cough;
Dizziness;
Edema;
Female;
Humans;
Hypertension*;
Male;
Ramipril*;
Reward
- From:Korean Circulation Journal
1991;21(4):774-780
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thirty three patients with mild to moderate essential hypertension were administered ramipril, a new ACe inhibitor, 2.5-5mg once daily for 6 weeks to evaluate the hypotensive efficacy and safety. The results were as follows : 1) The patients consisted of 18 males, 15 females, aged 54 on average and classified as mild in 19 and moderate in 14 patients. 2) At the end of 6 weeks trial, blood pressure dropped 13/6mmHg on average, rewarding 70% effectiveness and normalized below 150/90mmHg in 39%. 3) The most frequent side reaction was dry cough in 5 patients(15%) followed by asthenia, GI trouble, dizziness, edema, eye injection and one case of GPT elevation which normalized after completion of trial. 4) The rating of safety of safety was 79% and of overall usefulness was 73%. In conclusion, ramipril 5mg once daily regimen is well tolerated and effective in the treatment of mild to moderated essential hypertension.
