Analysis of cortical thickness in children with concomitant strabismus

Xiaohui Yin; Lingjun Chen; Mingyue MA; Yanjun Gao; Ming Zhang; Xiaoping WU; Wenfeng Ning; Junjian Zhang; Junle Yang

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Analysis of cortical thickness in children with concomitant strabismus

VernacularTitle:共同性斜视儿童的大脑皮层厚度分析
Author: Xiaohui YIN ; Lingjun CHEN ; Mingyue MA ; Yanjun GAO ; Ming ZHANG ; Xiaoping WU ; Wenfeng NING ; Junjian ZHANG ; Junle YANG
Keywords: children; strabismus; cortical thickness; magnetic resonance imaging
From: Journal of Practical Radiology 2017;33(8):1252-1255
CountryChina
Language:Chinese
Abstract: Objective To analyse the changes of cerebral cortical thickness and explore the connectivity of cortical thickness and the clinical syndrome of concomitant strabismus using high-resolution magnetic resonance imaging.Methods Participants were 26 children with primary strabismus and 28 healthy children strictly matched for sex, age, education and socioeconomic level.By using Freesurfer software, the whole-brain-based analysis was perfomrmed to compare the cortical thickness between the two groups.Results Compared with the healthy control group the children with strabismus were found that the cerebral cortex became thinner, including these brain regions related with stereovision,advanced visual-attention,attention and executive control function,as well as brain areas in insula and cingulate circuit.Conclusion Concomitant strabismus in children are not only caused by pathological changes of extraocular muscles,but anatomical changes of the central nervous system, especially the brain areas involved in the advanced visual processing related with visual-motor and visual-attention, and the advanced cognitive brain regions associated with attention and executive control, as well as the anatomical changes in insula and cingulate cortex circuit, which can explain the clinical syndrome of children with concomitant strabismus.