Feasibility study of adipose-derived mesenchymal stem cells in repairing traum-atic femoral neck fracture

VernacularTitle:ADSCs干预治疗创伤性股骨颈骨折的可行性探讨
Author: Zhao QIN ; Yanli SI ; Liping GUAN ; Wei GUO
Keywords: ADSCs; Traumatic femoral neck fracture; VEGF
From: Chinese Journal of Immunology 2017;33(8):1228-1231,1235
CountryChina
Language:Chinese
Abstract: Objective:To explore the feasibility of ADSCs in the clinical treatment of traumatic femoral neck fracture.Methods: After the intervention by ADSCs,femoral neck fracture repair was observed by hematoxylin-eosin staining.The vascular endothelial growth factor expression levels at the fracture segment were quantitatively measured by immunohistochemical staining,RT-qPCR was utilized to detect the mRNA formation in callus tissue.Results: In the study group,we observed less fracture repair than in the sham surgery group but more than in the blank group.Conclusion: ADSCs administration can promote osseous tissue and osteoblast repair,thereby contributing to the healing of traumatic femoral neck fracture in rats.