A retrospective study of ganciclovir in the therapy of adult infectious mononucleosis

VernacularTitle:更昔洛韦治疗成人传染性单核细胞增多症的回顾性研究
Author: Lichao YUAN ; Anlin MA ; Qian XU
Keywords: infectious mononucleosis; ganciclovir; antiviral therapy; adult
From: Chinese Journal of Infection Control 2017;16(8):730-732
CountryChina
Language:Chinese
Abstract: Objective To study clinical efficacy of ganciclovir in the therapy of infectious mononucleosis in adults.Methods 66 adults with infectious mononucleosis in a hospital from January 2010 to December 2014 were studied retrospectively,according to drug therapy,patients were divided into ganciclovir therapy group(n=31)and symptomatic therapy group(n=35),clinical features before therapy,therapeutic efficacy,and Epstein-Barr virus(EBV)DNA negative conversion time were analyzed.Results The time of defervescence,sore throat improvement,EBV-DNA negative conversion,subside of enlarged lymph node,and transaminase recovery in ganciclovir therapy group were all shorter than symptomatic therapy group(all P<0.05).Blood routine recovery time between two groups was not significantly different(P>0.05).Conclusion Ganciclovir has a good antiviral effect on the therapy of adult infectious mononucleosis,it can rapidly relieve patients from clinical symptoms including fever,sore throat and so on.