Origin and characteristics of c-kit+ cellsand their differentiation towards cardiovascular cells
- VernacularTitle:c-kit+细胞的来源、特征及其向心血管细胞的分化
- Author:
Pei ZHOU
;
Yuzhen TAN
;
Haijie WANG
- Keywords:
c-kit+ cells;
cardiomyocytes;
endothelial cells;
ischemic disease
- From:
Basic & Clinical Medicine
2017;37(8):1170-1174
- CountryChina
- Language:Chinese
-
Abstract:
c-kit+ cells are mainly derived from bone marrow and cardiac tissue.The cells include various subpopulations.Recent studies have shown that c-kit+ cells are a kind of ideal cells of transplantation therapy for myocardial infarction.However,there is a great debate on the differentiation efficiency of c-kit+ cells towards cardiomyocytes and endothelial cells.Therefore,it is necessary to evaluate the potential of c-kit+ cell differentiation and explore the effects of different developmental stages and microenvironments on differentiation of c-kit+ cells again.These studies could be significant for increasing efficiency of c-kit+ cell transplantation in repairing the infarcted myocardium.
