Association of rs7903146 polymorphisms in TCF7L2 gene with type 2 diabetes mellitus in Uygur population of Xinjiang
10.3969/j.issn.1000-4718.2017.08.016
- VernacularTitle:转录因子7类似物2基因的rs7903146位点多态性与新疆维吾尔族人群2型糖尿病的相关性研究
- Author:
Zhiqiang WANG
;
Yukai LI
;
Jun ZHU
;
Qi MA
;
Yinxia SU
;
Li WANG
;
Zhiyuan CHEN
;
Lina LIU
;
Hua YAO
- Keywords:
Single nucleotide polymorphisms;
Transcription factor 7-like 2 gene;
Type 2 diabetes mellitus;
Uygur
- From:
Chinese Journal of Pathophysiology
2017;33(8):1443-1448
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate whether rs7903146 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene are associated with susceptibility to type 2 diabetes mellitus (T2DM) in Chinese Uygur population.METHODS: In this case-control study, 935 cases of T2DM patients were recruited in T2DM group, and 971 healthy examination individuals were selected as normal control.The TCF7L2 gene polymorphism was detected by matrix-assisted laser desorption/ionization time-of-flight mass spectrum.RESULTS: Significant differences in the frequencies of CC, CT and TT genotypes and the frequencies of C and T alleles on TCF7L2 rs7903146 were found between T2DM group and control group(P<0.05).As compared with C allele, the patients with T allele had a significantly higher risk of T2DM with OR of 1.190 (95% CI: 1.034~1.371).As compared with CC genotype, the patients with CT genotype had a significantly higher risk of T2DM with OR of 1.374 (95% CI: 1.122~1.683), and the patients with CT+TT genotype had a significantly higher risk of T2DM with OR of 1.307 (95% CI: 1.090~1.567).The levels of fasting plasma glucose, serum creatinine and blood urea nitrogen were higher in all participants with CT+TT genotype of rs7903146 than those with CC genotype, which showed a significant difference (P<0.05).CONCLUSION: The polymorphisms of rs7903146 in TCF7L2 gene may be associated with T2DM in Uygur population from Xinjiang region.The T allele and CT genotype of rs7903146 are the risk factors for T2DM.
