Research progress on the role of circRNA in gastrointestinal tumor
10.3969/j.issn.1000-8179.2017.15.194
- VernacularTitle:circRNA在消化道肿瘤中的研究进展
- Author:
Ying XIONG
;
Hanmin CHEN
;
Wenqi YANG
;
Zhichang LIU
;
Zhengming ZHU
- Keywords:
circRNA;
miRNA;
sponge effect;
gastrointestinal tumor;
biomarkers
- From:
Chinese Journal of Clinical Oncology
2017;44(15):778-781
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is a widely present endogenous noncoding RNA that is covalently bonded at the 3' and 5' ends via trans-splicing to form a closed-loop structure with high stability, biological evolutionary conservatism,and tissue expression specificity. CircRNA has important biological functions, such as playing the role of microRNA (miRNA) sponge, regulating the expression of a par-ent gene, and improving transcription and translation levels. In gastrointestinal tumor, circRNA mainly plays the role of miRNA sponge, which affects the proliferation, differentiation, apoptosis, and invasion of cancer cells. In addition, circRNA was specifically expressed in the tumor, and the expression level significantly differs from that of paracancer. Therefore, a highly conserved and stable circRNA se-quence is expected to be an early diagnosis and prognostic marker for gastrointestinal tumor. In this study, we review research advanc-es on circRNA and its relationship with gastrointestinal cancers (esophageal, gastric, colorectal, and liver cancers).
