Comprehensive therapeutic strategies regarding immune checkpoint
10.3969/j.issn.1000-8179.2017.15.270
- VernacularTitle:免疫检查点综合治疗策略的研究进展
- Author:
Zhigong WEI
;
Lihong WANG
- Keywords:
immunotherapy;
immune checkpoint;
costimulatory molecule;
comprehensive therapeutic strategies
- From:
Chinese Journal of Clinical Oncology
2017;44(15):782-786
- CountryChina
- Language:Chinese
-
Abstract:
The rapid development of immunotherapy has exceeded that of standard treatment modes, which include surgery, radio-therapy, chemotherapy, and targeted therapy. Immunotherapy is more durable and less toxic than traditional cancer therapies. More-over, immune checkpoint therapy is an important component of immunotherapy and has been evaluated in preclinical and clinical tri-als and proven to exhibit broad prospects. However, its clinical benefits are limited to a small subset of patients with a subset of tumor types. Therefore, reasonable comprehensive therapeutic strategies are needed to overcome this limitation. Gene targeted therapy, ra-diotherapy, chemotherapy, and tumor vaccine affect the immune system through different mechanisms, and these could provide theo-retical bases for comprehensive treatments. In this review, immune checkpoint therapy and its potential comprehensive therapies with other cancer treatments are introduced.
