Clinical significance of combined detection of four kinds of serum tumor markers in diagnosis for breast cancer
10.3969/j.issn.1673-4130.2017.15.016
- VernacularTitle:4种血清肿瘤标志物联合检测在乳腺癌诊断中的临床意义
- Author:
Hongjian HUANG
;
Fangli YE
;
Wuying OU
- Keywords:
breast cancer;
tumor markers;
electrochemical luminescence;
combined detection
- From:
International Journal of Laboratory Medicine
2017;38(15):2060-2061,2064
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of combined detection of carbohydrate antigen(CA)125,CA153,carcinoembryonic antigen(CEA) and tumor specific growth factor(TSGF) in diagnosis for breast cancer.Methods A total of 125 patients with breast cancer were recruited as objects in this study from march 2015 to march 2016,65 patients in breast cancer group,60 patients in benign breast disease group,meanwhile 55 healthy person were enrolled in the control group.Serum tumor markers such as CA125,CA153,CEA and TSGF were detected and compared in the three groups.Results The serum CA125,CA153,CEA and TSGF levels in the breast cancer group were significant higher than those of benign breast disease group and healthy group,the differences were statistical significant(P<0.05).At the same time,the sensitivity and specificity of joint detection of four kinds of serum tumor marker were 90.2% and 88.9%,which were higher than those of single serum tumor marker detection(χ2=26.12,P<0.05).Conclusion The four kinds of serum tumor markers combined testing not only increases the sensitivity of breast cancer diagnosis,but also improved the specificity of diagnosis of breast cancer.
