Effects of IL-18BP blockade on apoptosis of synovial cell in IL-18-induced mice with Collagen-induced-arthritis

VernacularTitle:IL-18BP阻断由IL-18诱导大鼠胶原性关节炎对滑膜细胞凋亡表达的影响
Author: Dan LV ; Di JIN ; Baishan WANG ; Yujie GAO
Keywords: Rheumatoid arthritis; IL-18; IL-18BP
From: Chinese Journal of Immunology 2017;33(8):1161-1163
CountryChina
Language:Chinese
Abstract: Objective:To investigate the effects of IL-18BP blockade on apoptosis of synovial cell in IL-18 induced Collagen-induced-arthritis(CIA) in mice and its possible mechanism.Methods: CIA mice were established by freund′s complete adjuvant,and divided into 5 groups:normal group,CIA model group,IL-18-CIA group,MTX group and IL-18BP group,each for 10,total 50 mice.The expression of Fas and FasL in the synovial tissue of the left posterior ankle joint taken from each group were detected by immunohistochemistry analysis.Results: IL-18BP group compared with the model group,the mice of joint swelling was inhibited,the expression level of Fas and FasL increased significantly,the difference was statistically significant (P<0.01);IL-18BP group has a significant curative effect and basically recovered to normal level(P<0.05).Conclusion: IL-18BP can promote the apoptosis of synoviocytes by regulating the expression of apoptosis genes Fas and FasL,which is helpful for the treatment of rheumatoid arthritis.