Research on correlation between autophagy related gene frequency distribution characteristics and pulmonary tuberculosis
10.3969/j.issn.1671-8348.2017.22.007
- VernacularTitle:自噬相关基因频率分布特征与肺结核相关性研究
- Author:
Ying LI
;
Qing HUANG
;
Weixian CHEN
;
Shengjing LI
- Keywords:
tuberculosis,pulmonary;
autophagy;
genes;
polymorphism,single nucleotide
- From:
Chongqing Medicine
2017;46(22):3046-3049
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between autophagy related gene(ATG) locus polymorphism and the pulmonary tuberculosis(PTB) susceptibility according to the frequency distribution characteristics of autophagy related gene in the patients with PTB.Methods Eighteen single nucleotide polymorphism (SNP) loci of autophagy related genes in 202 patients with PTB as the case group and 222 healthy controls were genotyped by SequenomMassArray mass spectrometry array technology.The correlation between the each locus genotype and the PTB susceptibility was statistically analyzed.Results In the PTB patients group and healthy control group,after correcting the factors of sex and age,the binary Logistic regression analysis found that the frequency distribution of genotype and allele had statistical difference between rs5973822 and rs807185 sites in ATG4A gene (P＜0.05).The stratified analysis by body mass index (BMI) found that this difference was more significant in the high BMI population,moreover the distribution frequency in the patient group was lower than that in the control group,and the other 16 SNP loci had no statistical difference.Conclusion ATG4A gene rs5973822 and rs807185 loci polymorphism may be negatively correlated with PTB susceptibility,moreover which is more significant in the high BMI group.
