Study on the correlation between human papillomavirus infection and cervical cytokines
10.3969/j.issn.1673-4130.2017.15.005
- VernacularTitle:人乳头瘤病毒感染与宫颈局部细胞因子相关性研究
- Author:
Rui TAO
;
Dan ZHU
;
Yi SUN
;
Xin FAN
;
Guiqian ZHANG
;
Yuhong GAO
- Keywords:
human papillomavirus;
cytokines;
cervical;
immune function
- From:
International Journal of Laboratory Medicine
2017;38(15):2028-2029,2033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between human papillomavirus(HPV) infection and cervical immune function.Methods A total of 209 women with HPV positive results in HPV-infected group,40 women with HPV negative results in control group,cervical samples were detected and genotyped with HPV GenoArray Diagnostic Kit.Concentrations of cytokines including interleukin(IL)-2,IL-4,interferon(IFN)-γ,and transforming growth factor(TGF)-β in cervical specimens were measured by ELISA.Results IL-2,IL-4 and IFN-γ levels in the HPV-infected group were different with those of the control group(P=0.000 1,0.001 0,0.000 1),TGF-β in HPV-infected group and control group showed no significant difference(P=0.680 0).IFN-γ in high-risk HPV group was significant lower than that in the low-risk HPV group(P=0.007 0).Conclusion HPV infection might be one of the main reasons of cervical local immune dysfunction.
