A Meta-analysis on effect of antibody blood screening in preventing transmission of cytomegalovirus by transfusion
10.3969/j.issn.1673-4130.2017.15.008
- VernacularTitle:人巨细胞病毒抗体筛查预防输血性人巨细胞病毒感染的Meta分析
- Author:
Hao BI
;
Gang LI
;
Qin YU
;
Yanyi YAO
;
Hao PEI
- Keywords:
cytomegalovirus;
infection;
transfusion;
antibody screening;
Meta-analysis
- From:
International Journal of Laboratory Medicine
2017;38(15):2036-2039
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of using cytomegalovirus-seronegative blood components in preventing transfusion-acquired cytomegalovirus infection,which laid foundation for the application of blood antibody screening of cytomegalovirus.Methods The documents of studies about the comparison in transfusion-acquired cytomegalovirus ratio between using cytomegalovirus-seronegative blood components with using cytomegalovirus-unscreened /non-WBC-reduced blood were retrieved from the databases of PubMed,MEDLINE,Ovid,ProQuest,EBSCO,Cochrane Library,EMbase,CNKI,VIP,CBM and WanFang Library,and the reference in studies were retrieved by hands at the same time.The documents were screened,extracted and evaluated according to inclusion and exclusion criteria,and then given a Meta-analysis by using Rev Man 5.1 software.Results There were totally 7 controlled studies(430 patients) included.The results of Meta-analysis showed that compared with using cytomegalovirus-unscreened/non-WBC-reduced blood,the effect of using cytomegalovirus-seronegative blood components in preventing transfusion-acquired cytomegalovirus infection had a statistical difference(OR=0.07,95%CI:0.03-0.18,P<0.01).Conclusion Application of blood antibody screening of cytomegalovirus is effective in preventing transfusion-acquired cytomegalovirus infection,especially organ transplantation and neonate patients.
