Clinical significance of the expression of D-amino acid oxidase gene in hepatocellular carcinoma tissues
10.3969/j.issn.1673-4130.2017.15.019
- VernacularTitle:肝癌组织中D-氨基酸氧化酶基因表达的临床意义
- Author:
Bin FAN
;
Jiayao ZHANG
;
Yong ZHANG
;
Jinmao LI
;
Jun DING
;
Jian ZHANG
;
Qinghe LI
- Keywords:
hepatocellular carcinoma;
D-amino acid oxidase;
expression
- From:
International Journal of Laboratory Medicine
2017;38(15):2068-2070
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of the expression of D-amino acid oxidase(DAO) in hepatocellular carcinoma(HCC) tissues.Methods The gene expression profiles and related clinical data of 214 HCC cases were collected.Univariate and multivariate analyses were conducted to investigate the association between DAO expression levels,clinical traits,the prognosis.Results Univariate analysis indicated that there were a lower level of blood alpha fetoprotein(AFP,P=0.001),a smaller number of nodules(P=0.042),a better TNM stage(P=0.014),a lower metastasis risk(P=0.001) and a better prognosis(P=0.011)in the samples with high DAO expression.Multivariate analysis also indicated a lower AFP level(OR:0.162,95%CI:0.078-0.336) and metastasis risk(OR:0.140,95%CI:0.069-0.284) in the samples with high DAO expression,as well as a better prognosis(OR:0.833,95%CI:0.700-0.992).Conclusion DAO expression was associated with blood AFP levels,metastasis risk and prognosis in HCC,and its high expression was a protective factor for HCC.
