Value of serum IL-33 and its soluble receptor ST2 in patients with chronic hepatitis B
10.3969/j.issn.1673-4130.2017.15.021
- VernacularTitle:慢性乙型肝炎患者血清IL-33及其可溶性受体ST2水平变化及其临床意义
- Author:
Jingxian WANG
;
Yuying HUANG
;
Yanping LI
;
Xueyao LIU
;
Chunyan JIANG
- Keywords:
chronic hepatitis B;
interleukin IL-33;
soluble receptor ST2;
alanine aminotransferase
- From:
International Journal of Laboratory Medicine
2017;38(15):2074-2075
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of serum interleukin(IL)-33 and its soluble receptor ST2(sST2) level in patients with chronic hepatitis B.Methods A total of 65 cases with chronic hepatitis B were recruited into study group,meanwhile 60 healthy persons were enrolled in the control group from January 2014 to October 2016 in our hospital.IL-33,sST2 and alanine aminotransferase(ALT) were detected and compared in the two groups.Results The level of IL-33,sST2 and ALT were significant higher than those of the control group(t=6.542,7.218,6.324;P<0.05).IL-33 and sST2 levels in chronic hepatitis B patients with abnormal ALT level were significant higher than those with normal ALT(t=16.328,9.874,P<0.05).Conclusion The detection of IL-33 and sST2 in patients with chronic hepatitis B could help to understand the immune status of patients,and provide a theoretical basis for the treatment of chronic hepatitis B.
