Value of FIB-4 and APRI index in evaluating the severity of liver fibrosis among patients with chronic hepatitis B
10.3969/j.issn.1673-4130.2017.15.022
- VernacularTitle:FIB-4及APRI指数对慢性乙型肝炎患者肝纤维化严重程度的评估价值
- Author:
Lihua HE
;
Zhilin NIU
;
Yang YE
- Keywords:
liver fibrosis;
FIB-4 index;
APRI index;
chronic hepatitis B
- From:
International Journal of Laboratory Medicine
2017;38(15):2076-2078,2081
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of FIB-4 and APRI index on evaluating the severity of liver fibrosis among patients with chronic hepatitis B(CHB).Methods A total of 218 CHB were enrolled in the study.Based on the staging of liver fibrosis,the patients were divided into 2 groups as S0-S2 group(n=120) and S3-S4 group(n=98).Differences in clinical data,laboratory indexes,FIB-4 and APRI index were compared between two groups.The correlation between FIB-4 index,APRI index and liver fibrosis were analyzed by Spearman correlation test.Receiver operator curve(ROC) test was used to determine the evaluating value of FIB-4 index and APRI index for the severity of liver fibrosis.Results To evaluate the staging≥S2 of liver fibrosis,the value of FIB-4 index was better than APRI index(Z=1.998,P=0.046).And to evaluate the staging≥S3 and S4 of liver fibrosis,the value of FIB-4 index for evaluating the staging≥S3(Z=1.177,P=0.239) or S4(Z=0.267,P=0.789) was the same as APRI index.Conclusion FIB-4 index and APRI index are both effective on evaluating the severity of liver fibrosis among patients with CHB,but the value of FIB-4 index is better than APRI index for evaluating early liver fibrosis.
