Effect of alprostadil on early proinflammatory cytokines and its therapeutic effect in patients with severe acute pancreatitis
10.11855/j.issn.0577-7402.2017.02.09
- VernacularTitle:前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效观察
- Author:
Minli LI
;
Xiaohua ZHANG
;
Xinxin JIN
;
Xiaobing XU
;
Fangyu WANG
- Keywords:
pancreatitis,acute necrotizing;
alprostadil;
inflammatory cytokines
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of alprostadil on expression of proinflammatory cytokines in patients with severe acute pancreatitis (SAP) and evaluate the clinical efficacy.Methods Seventy-three SAP patients were collected from January 2014 to May 2016,and then were randomly divided into control group (n=37) and experimental group (n=36).On the basis of routine treatment,the experimental group patient was given alprostadil at a dose of 15μg/d.The expression of C-reactive protein (CRP),white blood cell (WBC) count,amylase,alanine aminotransferase (ALT),aspartate aminotransferase (AST),creatinine,serum proinflammatory cytokine tumor necrosis factor alpha (TNF-α),interleukin-1 beta (IL-1[β),interleukin-6 (IL-6) were detected in serum on the 1st,3rd and 7th day.Results The biochemical indexes and expression ofproinflammatory cytokines were significantly increased in the two groups on the 1st day,and decreased gradually,with a significant difference between the time points (P＜0.05),but the between-group difference was not significant (P＞0.05).These indexes were decreased significantly with the passage of time and there were significant differences between the two groups at the 3rd and 7th day (P＜0.05).Conclusion Alprostadil can effectively reduce the severity of early inflammatory reaction in SAP patients,and has important significance for improving the prognosis.
