Research progress of NLRP3 inflammasome in organ ischemia-reperfusion injury
10.11855/j.issn.0577-7402.2017.02.17
- VernacularTitle:NLRP3炎性小体在器官缺血再灌注损伤中的作用
- Author:
Peilei LI
;
Fang LIU
;
Zhiren FU
- Keywords:
NLRP3 inflammasome;
reperfusion injury;
apoptosis-associated speck-like protein containing a caspase recruitment domain;
interleukin-1 β
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(2):177-180
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury is a common pathophysiological process in organ transplantation,ischemic stroke and organ resection surgery,and also an important factor causing organ dysfunction and severe postoperative complications.How to avoid or mitigate organ ischemia-reperfusion injury has always been a research hotspot.NLRP3 Inflammasome has been considered to be an important link in inflammatory response.It has an indispensable role in maturation process of IL-lβ and IL-18.We reviewed the research in recent yeas about the role of NLRP3 Inflammasome in organ ischemia-reperfusion injury in this paper.
