Recent advances in immune regulation of mesenchymal stem cells on autoimmune dry eve
10.13389/j.cnki.rao.2017.0122
- VernacularTitle:间充质干细胞对自身免疫性干眼的免疫调控作用研究进展
- Author:
Xilian WANG
;
Xiaoxiao LU
;
Liyuan YANG
;
Hong NIAN
;
Ruihua WEI
- Keywords:
mesonchymal stem cells;
autoimmune dry eye;
immunoregulation
- From:
Recent Advances in Ophthalmology
2017;37(5):480-483
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSCs) have good immune regulatory function,can inhibit many immune cell proliferation,direct effects on activation and proliferation of T cell,play a role in immune regulation by Treg cells or by the secretion of soluble factors regulating Thl/Th2 secretion and reaction equilibrium,inhibit the inflammation through the anti-inflammatory,regulation of cytokines expression at the same time,so reduce the expression levels of matrix metalloproteinase-2 and-9,which may promote lacrimal gland tissue damage,and thus play a role in immune regulation.MSCs can reduce the autoimmune dry eye clinical index,recovery secretion function of part lacrimal gland.This article reviews the research advances in inmmmne regulation of MSCs on autoimmune dry eye.
