Meta-analysis of pregnancy induced hypertension with risk of morbidity in congenital heart diseases
10.3969/j.issn.1000-3606.2017.05.013
- VernacularTitle:妊娠期高血压与胎儿先天性心脏病发病风险的meta分析
- Author:
Li MA
- Keywords:
pregnancy induced hypertension;
congenital heart disease;
risk of morbidity
- From:
Journal of Clinical Pediatrics
2017;35(5):372-376
- CountryChina
- Language:Chinese
-
Abstract:
Objective Systematical evaluation of studies published abroad on pregnancy induced hypertension and incidence of congenital heart diseases (CHDs), to investigate the relationship between pregnancy induced hypertension and the risk of CHDs morbidity. Methods Studies of pregnancy induced hypertension and CHDs were identified by searching major electronic databases (PubMed, Elsevier and Web of Science) by the medical subject headings and keywords without language restriction. Stata was conducted to determine the risk of CHDs related to pregnancies induced hypertension. Results Thirteen (13) case-control and 10 cohort studies were identified. Pregnancy induced hypertension was associated with an increased risk of CHDs morbidity (RR=1.65,95%CI: 1.50~1.83). Subgroup analysis showed that both of the pregnancy hypertension treated group and the untreated group increased the risk of CHDs morbidity (RR=2.11,95% CI: 1.72~2.58; RR=1.61,95%CI:1.34~1.94). Calcium channel blockers, adrenergic receptor blockers and diuretics did not increase the risk of CHDs morbidity (P>0.05), β-blockers and angiotensin-converting enzyme inhibitor increased the risk of CHDs morbidity (P<0.05). Conclusions Pregnancies induced hypertension increased risk of CHDs morbidity.
