Morphology analysis of bone marrow smear and clinical characteristics of 5 cases of blastic plasmacytoid dendritic cell leukemia
10.3760/cma.j.issn.1009-9158.2017.04.007
- VernacularTitle:浆母细胞样树突细胞白血病的骨髓细胞形态学及临床分析
- Author:
Xianyong JIANG
;
Qiang PEI
;
Xuan WANG
;
Changwen GE
;
Jian LI
;
Daobin ZHOU
- Keywords:
Dendritic cells;
Hematologic neoplasms;
Bone marrow cells;
Flow cytometry;
Bone marrow examination
- From:
Chinese Journal of Laboratory Medicine
2017;40(4):242-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of morphology in patients with blastic plasmacytoid dendritic cell leukemiafrom bone marrow cell.Methods Clinical data of 5 patients with BPDCN leukemia in Peking Union Medical College Hospital from 2011 to 2016were collected.The morphological characteristics of the cell size,nuclei,chromatin and cytoplasm of the BPDCNtumor cells in the bone marrow smears were observed under the microscope.Results The clinical manifestation of the 5 cases involved skin lesions (5/5,100％),lymphadenopathy (4/5,80％),hepatomegaly (3/5,60％),splenomegaly (4/5,80％).Immunophenotype showed all cases were positive for CD4,CD56 and CD123.The morphologiesof BPDCN cell characterized by heterogenous clls,were frequent,including,frequent mediumsized cells with a round or irregular nucleus,lacy chromatin,basophilic cytoplasm with lack of granules,marked large pseudopodia and vacuolation which may arranged as pearl necklace along the cytoplasmic outline.They might mimicking pseudomonoblast,Pseudolymphoblast or Pseudolymphoma cell.Conclusions Plasmacytoid dendritic cells had some peculiar morphological features,the patients suffered from the clinical manifestation of skin lesion may highly suggested the diagnosis of BPDCN,Flow cytometry and pathological biopsy are necessary for the final diagnosis of BPDCN.
