Clinical Profile and Prognostic Factor of Endometrial Cancer.
- Author:
Su Yeon KIM
;
Sang Young RYU
;
Jae Weon KIM
;
Noh Hyun PARK
;
Yong Sang SONG
;
Soon Beom KANG
;
Hyo Pyo LEE
- Publication Type:Original Article
- Keywords:
Endometrial cancer;
Prognostic Factors;
Surgical staging
- MeSH:
Endometrial Neoplasms*;
Female;
Gynecology;
Humans;
Lymph Nodes;
Mortality;
Multivariate Analysis;
Neoplasm Metastasis;
Prognosis;
Recurrence;
Risk Factors;
Seoul
- From:Korean Journal of Gynecologic Oncology and Colposcopy
1997;8(3):215-226
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The importance of surgico-pathologic staging in endometrial cancer to identify risk factors of the therapeutic and prognostic value has been recognized only recently. Recognition of subsets of patients should minimize treatment related morbidity and mortality for those patients with a good prognosis, while identifying patients who are at high risk for recurrence and therefore likely to benefit from adjuvant therapy. METHODS: This rettospective study was based on clinical review of 76 patients with endometrial cancer from 1983 through 1994 who underwent surgical treatment in Department of Obstettics and Gynecology at Seoul National University Hospital. All cases were restaged using the newly adopted FIGO surgical staging. Univariate and multivariate analysis were carried to compare the importance of prognostic variables. RESULTS: Significant prognostic factors in endometrial cancer were histologic subtype, depth of myometrial invasion, cervical invasion, parametrial invasion, adnexa metastasis, lymph node metastasis and peritoneal cytology(p<0.05). Age and histologic grade were not significant prognostic factors(p>0.05). Multivariate analysis showed that surgical stage and depth of myometrial invasion were important factors that predict recurrence(p<0.05). CONCLUSION: This study has yielded important information for therapeutic approach to endometrial cancer.
