Level of pulmonary surfactant protein D and human type Ⅰ protein in bronchoalveolar lavage fluid and serum in children with mycoplasma pneumoniae pneumonia
10.3760/cma.j.issn.1673-4408.2017.04.018
- VernacularTitle:肺表面活性蛋白D和人类Ⅰ型蛋白在肺炎支原体肺炎患儿支气管肺泡灌洗液和血清中的水平研究
- Author:
Ying GUI
;
Xiaolan LI
- Keywords:
Mycoplasma pneumoniae pneumonia;
Bronchoalveolar lavage fluid;
Surfactant protein D;
human type Ⅰ protein
- From:
International Journal of Pediatrics
2017;44(4):291-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the levels of pulmonary surfactant protein D (SP-D) and 56-kD human type Ⅰ protein(HTI-56) in bronchoalveolar lavage fluid and serum of children with mycoplasma pneumoniae pneumonia,as well as their potential as biomarkers of mycoplasma pneumoniae pneumonia.Methods A retrospective study was conducted in 57 children with mycoplasma pneumoniae pneumonia from June 2011 to June 2016 in our hospital.In this study,the levels of SP-D and HTI-56 in bronchoalveolar lavage fluid and serum were determined and compared between unilateral lung infection and bilateral lung infection.Results SP-D and HTI-56 levels were significantly higher in bronchoalveolar lavage fluid samples (P ＜ 0.05)compared with bronchoalveolar lavage fluid samples from uninfected lungs (P ＜ 0.05).However,the serum levels of SP-D and HTI-56 in children with unilateral lung infection and bilateral pulmonary infection were not significantly different (P ＞0.05).Conclusion High levels of SP-D and HTI-56 in bronchoalveolar lavage fluid samples from infected lungs may reflect damage to alveolar epithelial cells caused by mycoplasma pneumoniae.
