Allogeneic hematopoietic stem cell transplantation for hemophagocytic syndrome
10.3760/cma.j.issn.1673-4408.2017.04.011
- VernacularTitle:异基因造血干细胞移植治疗噬血细胞综合征
- Author:
Lanjun JIANG
- Keywords:
Allogeneic hematopoietic stem cell transplantation;
Hemophagocytic lymphohistiocytosis
- From:
International Journal of Pediatrics
2017;44(4):263-266
- CountryChina
- Language:Chinese
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Abstract:
Hemophagocytic syndrome,also called hemophagocytic lymphohistiocytosis,includes primary hemophagocytic lymphohistiocytosis and secondary hemophagocytic lymphohistiocytosis.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only effective therapy for familial hemophagocytic lymphohistiocytosis (FHL) and refractory EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH),but the differential diagnosis is still difficult.Meanwhile,much more complications and high mortality have attracted attention of many researchers.In this review,the recent advance in allo-HSCT for FHL and EBV-HLH about diagnosis,conditioning regimen,complication after HSCT,death causes and prognosis has been described.
