Research progress of inflammatory cytokines and neonatal bilirubin brain damage
10.3760/cma.j.issn.1673-4408.2017.04.008
- VernacularTitle:炎性细胞因子与新生儿胆红素脑损伤的研究进展
- Author:
Liting CHEN
- Keywords:
Inflammatory cytokine;
Neonate;
Bilirubin;
Brain damage
- From:
International Journal of Pediatrics
2017;44(4):253-255
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,more and more attention has been paid to the inflammatory reaction in the process of neonatal unconjugated bilirubin brain damage.Studies have shown that inflammation plays an important role in the occurrence and prognosis of neonatal bilirubin brain injury.A large amount of unconjugated bilirubin pass through the blood brain barrier,causing glial ceils activation,emerging immune response,releasing inflammatory cytokines,leading the apoptosis,necrosis and damage repair of neuronal.This article reviews the occurrence and protection mechanism of inflammatory cytokines(tumor necrosis factor-α,interleukin-6,8,1 β,10,et.al) in neonatal bilirubin brain damage.
