Damage mechanism on vascular endothelium by platelet-derived microparticle
10.3760/cma.j.issn.1673-4408.2017.04.014
- VernacularTitle:血小板衍生微颗粒在血管内皮损害中的作用机制
- Author:
Jing JIN
- Keywords:
Platelet-derived microparticles;
Vascular endothelium;
Atherosclerosis;
Diabetes mellitus;
Kawasaki disease
- From:
International Journal of Pediatrics
2017;44(4):273-275,280
- CountryChina
- Language:Chinese
-
Abstract:
Platelet-derived microparticle (PMP)is a heterogeneous vesicle (＜ 1 μm)generated from the plasma membrane when platelets are activated by various stimulation,which is composed of serous cystic fragments and α-granules.The formation,release and level of circulating PMP can reflect the platelet activation.The functions of PMP include facilitating coagulation,promoting adhesion of platelet and leukocyte to the subendothelial membrane,promoting angiogenesis and stimulating the proliferation of vascular smooth muscle.High level of PMP appears in many cardiovascular diseases such as atherosclerosis,diabetes mellitus,Kawasaki disease and so on.This paper is to review the mechanism of PMP in the vascular endothelial injury.
