A Study of Detection of Human Papilloma Virus in the Patients with the Uterine Cervical Cancer by the Hybrid Capture System Method.
- Author:
Sang Moo CHO
;
Sei Jun HAN
- Publication Type:In Vitro ; Original Article
- Keywords:
Invasive cervical carcinoma;
Human papilloman virus deoxyribonucleic acid;
Hybrid capture
- MeSH:
Biopsy;
DNA;
Female;
Human papillomavirus 16;
Human papillomavirus 18;
Human Papillomavirus DNA Tests;
Humans*;
Immunologic Tests;
Nucleic Acid Hybridization;
Papilloma*;
Physical Examination;
Triage;
Uterine Cervical Neoplasms*
- From:Korean Journal of Gynecologic Oncology and Colposcopy
1997;8(3):266-270
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tbe presence of certain HPV types in the female genital tract was associated with a number of diseases, including condyloma, cervical, vaginal and vulvar intraepithelial neoplasia and carcinoma. It is generally accepted that these viruses are predominantly sexually transmitted. HPV cannot be cultured in vitro, and immunological tests are inadequate. Indirect evidence of anogenital HPV infection can be obtained through the physical examination and by the presence of characteristic cellular changes associated with viral replication in Pap smear or biopsy specimens. Alternately cervical scrapes can be analyzed by nucleic acid hybridization to directly detect the presence of HPV DNA, Historically, HPV 16 and HPV 18 have been regarded as high risk cancer associated HPVs and HPV types 6, 11, 42, 43 and 44 as low risk HPVs. Subsequently HPV types 31, 33, 34, 35, 45, 51, 52, 56 and 58 have been demonstrated to have and intemediate association with cancer, This study was performed for high and intermediate types HPV DNA detection on cervical carcinoma with Virapap Probe B. HPV DNA were detected 82.3% on cervical carcinoma and 7,1% on control samples. HPV DNA test will be apply as a triage for cervical cancer detecting test.
