Expression of microRNA-3620 in blood plasma and its clinical significance in patients with anti-tuberculosis drug-induced hepatotoxicity
10.3760/cma.j.issn.1000-6680.2017.03.008
- VernacularTitle:微小RNA-3620在抗结核药物致肝损伤患者血浆中的表达及临床意义
- Author:
Ping XIE
;
Tong ZHU
;
Caiping CHEN
;
Ru BAI
;
Hui ZHAO
;
Weixing ZHU
;
Liangming LIU
- Keywords:
miRNA-3620;
Anti-tuberculosis drug-induced hepatotoxicity;
Tuberculosis;
pulmonary
- From:
Chinese Journal of Infectious Diseases
2017;35(3):161-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of microRNA (miRNA)-3620 in the plasma of patients with anti-tuberculosis drug-induced hepatotoxicity (ATDH).Methods A total of 35 patients with ATDH and 35 non-ATDH paired individuals were included in this study.Plasma miRNA-3620 levels were detected using real-time Polymerase chain reaction.Comparison between two groups was done with t test.Receiver operation characteristic (ROC) curve analysis was performed to determine the diagnostic value of miRNA-3620 in ATDH.Results The relative expression of plasma miRNA-3620 of patients with ATDH and non-ATDH were 1.65±1.43 and 0.71±0.45, respectively, with significantly statistical difference (t=3.703, P<0.01).The cut off value of miRNA-3620 expression was 1.15 and the area under ROC curve were 0.71(95% CI: 0.43-1.45).Based on this cutoff value, the sensitivity and specificity of miRNA-3620 in diagnosing ATDH were 60.0% and 82.9%, respectively;the positive predictive value was 77.8% and the negative predictive value was 67.4%.Twenty-one ATDH cases and 29 non-ATDH cases was correctly diagnosed, with the accuracy of 71.4%.Conclusion The expression of miRNA-3620 in plasma is significantly increased in ATDH patients.
