Role and mechanism of eosinophils in the pathogenesis of atopic dermatitis
10.3969/j.issn.1000-3606.2017.05.016
- VernacularTitle:嗜酸性粒细胞在特应性皮炎发病中的作用与机制
- Author:
Qianyue XU
- Keywords:
atopic dermatitis;
eosinophil;
pathogenesis;
Th2 cells;
cytokines
- From:
Journal of Clinical Pediatrics
2017;35(5):389-393
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease. Multiple studies have demonstrated a significant correlation between the eosinophil (EOS) and AD. Th2 cells secret cytokines and chemokines mediating the activation, differentiation and growth of EOS. EOS is recruited from bone marrow and blood into the dermis, and releases granule proteins, cytokines etc., resulting in the deposition of collagen and fibrosis thickening. This article reviews the recent studies of the main role and mechanism of EOS in the pathogenesis of AD, aiming to a further understanding of this disease and provides insights for the development of new drugs.
