The regulative function of mitochondria in innate immune response to chronic HBV infection
- VernacularTitle:线粒体在慢性HBV感染者固有免疫应答中的调节作用
- Author:
Zhen XUN
;
Tianbin CHEN
;
Qishui OU
- Keywords:
Mitochondria;
Hepatitis B;
chronic;
Immunomodulation
- From:
Chinese Journal of Laboratory Medicine
2017;40(5):407-410
- CountryChina
- Language:Chinese
-
Abstract:
Innate immunity initially resists the infection of pathogenic microorganism in host immune response.Recent researches confirmed that mitochondria participated in a wide range of innate immune pathways,mainly including contributing to innate immune activation,regulating antiviral signaling pathways and antibacterial immunity.Therefore,further studies on the relationship among mitochondria,hepatitis B virus(HBV)infection and innate immune response might contribute to elucidate the mechanism of chronic HBV infection and explore the mechanism of host immune to clear HBV.Here,mitochondria playing a vital role in regulations of innate immune response,HBV infection tending to chronicity by suppressing innate immune response and chronic HBV infection by regulating the innate immune response through injuring mitochondria,were reviewed.
