The clinical application of function-preserving pancreatic surgery in treating pancreatic neuroendocrine tumors
10.3760/cma.j.issn.1674-1935.2017.02.011
- VernacularTitle:功能保留性胰腺手术在胰腺神经内分泌肿瘤外科治疗中的应用
- Author:
Qiang HUANG
;
Chenglin ZHU
- Keywords:
Pancreatic neoplasms;
Neuroendocrine tumors;
Surgical procedures;
operative;
Function-preserving
- From:
Chinese Journal of Pancreatology
2017;17(2):119-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application of function-preserving pancreatic surgery for treating pancreatic neuroendocrine neoplasms (pNENs).Methods Twenty-eight patients with pNENs treated by the function-preserving pancreatic surgery at Anhui Province Hospital from January 2002 to December 2015 were analyzed retrospectively.Results Among the 28 patients, enucleation surgery was performed in 18 cases, distal pancreatectomy was performed in 8 cases, and middle pancreatectomy was performed in 2 patients.Total average operation time was (197±68) min, and the blood loss was (106±99) ml.The postoperative pancreatic fistula was observed in 7 patients, seroperitoneum was in 4 patients, incisional infection was in 1 patient, pulmonary infection was in 2 patients, and all the patients were cured by conservative treatment.There was no death during perioperative period.The postoperative hospital stay was (13±6)d.Analysis of pathological examination and clinical symptoms showed that 24 cases were diagnosed as functional pNENs (including 23 with insulinoma and 1 with gastrinoma), and 4 cases were as non-functional pNENs.The tumor grade G1 was categorized in 19 cases, G2 was in 9 cases.The TNM was I stage in all patients.There were no vascular or nerve invasion or lymph node metastasis.The follow-up period ranged from 4 to 144 months.2 patients were lost, and other patients were all alive.No diabetes or hypoglycemia occurred.Conclusions The function-preserving surgery for pNENs was safe and feasible, especially for well-differentiated functional pNENs.
