Research progress on mechanisms of calcific aortic valve disease
10.3760/cma.j.issn.1001-4497.2017.03.018
- VernacularTitle:钙化性主动脉瓣疾病发病机制研究进展
- Author:
Siming ZHU
;
Shengli JIANG
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2017;33(3):188-192
- CountryChina
- Language:Chinese
-
Abstract:
Calcific aortic valve disease(CAVD) is the most common valvular disorder.There is no medical treatment to prevent and/or reverse the progression of CAVD and the etiology still requires further study.CAVD has long been described as a degenerative disease related to aging.In the past few years,our comprehension of the etiology and mechanisms leading to CAVD has progressed at a fast pace.In this article,we review the latest discoveries of CAVD,from aspects of lipid retention,inflammation,calcification,osteogenic transition and their basic molecular processes.
