The expression of immune regulatory factors in thymoma with myasthenia gravis
10.3760/cma.j.issn.1001-4497.2017.03.009
- VernacularTitle:胸腺瘤并发重症肌无力患者免疫调节因子的表达
- Author:
Hui ZHANG
;
Peng ZHANG
;
Yimei LIU
;
Yuan CHEN
;
Xin LI
;
Peng LYU
;
Yuanguo WANG
- Keywords:
Thymoma;
Myasthenia gravis;
Autoimmune disease;
Aire;
Foxp3;
AchR
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2017;33(3):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Aire,Foxp3,AchR and other immune factors in human thymoma tissue and plasma and explore their role in myasthenia gravis with thymoma.Methods T lymphocyte subsets,immunoglobulin and other immune factors in plasma were compared,and the Expression of Aire,Foxp3 and AchR were examined in thymoma by reverse transcriptional polymerase chain reaction and immunohistochemical staining,and the results were analyzed by SPSS statistics software.Results The ratio of CD4 + to CD8 + T lymphocyte was much higher in plasma,while the expressions of Aire,Foxp3 and AchR at mRNA and protein level were much lower in thymoma patients with myasthenia gravis,and related to Ossermann subtype,WHO subgroup and Masaoka stage.The differences were statistically significant (P ＜ 0.05).Conclusion The ratio of CD4 + to CD8 + T lymphocyte and the abnormal expressions of Aire and Foxp3could used as an indicator of immune state in thymoma patient with myasthenia gravis and play an important role in the development of thymoma with myasthenia gravis,but the mechanism is indefinite.
