Treatment strategies of EGFR-mutated non-small cell lung cancer with brain metastases
10.3760/cma.j.issn.1673-422X.2017.04.014
- VernacularTitle:EGFR突变的非小细胞肺癌脑转移的治疗策略
- Author:
Huibo ZHANG
;
Xiangpan LI
;
Qibin SONG
- Keywords:
Carcinoma;
non-small-cell lung;
Therapy;
Metastasis;
Epidermal growth factor receptor
- From:
Journal of International Oncology
2017;44(4):294-296
- CountryChina
- Language:Chinese
-
Abstract:
As the leading cause of death among lung cancer patients, brain metastasis occurs in approximately 10 percent of non-small cell lung cancer (NSCLC) patients at first diagnosis.Whole-brain radiation therapy (WBRT) is still the standard treatment for patients with brain metastasis, however, the efficacy of WBRT reaches a plateau.It has been proved that tyrosine kinase inhibitors (TKIs) make considerable therapeutic effect for NSCLC patients with brain metastasis.The combination therapy of TKIs with WBRT may provide new major treatment for epidermal growth factor receptor (EGFR) mutant NSCLC with brain metastasis.
