Effects of preoperative prophylactic infusion of cephalosporins antibiotics on electrocardiogram during anesthesia induction with propofol:cefuroxime sodium versus cefathiamidine
10.3760/cma.j.issn.0254-1416.2017.03.002
- VernacularTitle:术前预防性输注头孢类抗生素对丙泊酚麻醉诱导时心电的影响:头孢呋辛钠与头孢硫脒的比较
- Author:
Yanqiu LIU
;
Yang ZHAO
;
Hong GAO
;
Xingyu LI
;
Kaiqiang ZHANG
;
Chunlei WEN
- Keywords:
Anti-bacterial agents;
Propofol;
Electrocardiography
- From:
Chinese Journal of Anesthesiology
2017;37(3):260-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of preoperative prophylactic infusion of cephalosporins antibiotics on electrocardiogram(ECG)during anesthesia induction with propofol. Methods Fifty female patients,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,aged 20-50 yr,weighing 43-75kg,scheduled for elective surgery,were divided into cefuroxime sodium group(group CEFU)and cefathiamidine group(group CEFA),with 25 patients in each group. After cefuroxime sodium was infused in group CEFU or cefathiamidine was infused in group CEFA,propofol was given by target-controlled infusion(plasma concentration 4 μg/ml).Before infusion of cefuroxime sodium or cefathiamidine,after completion of infusion and at 5min after propofol reached the target concentration,12-lead ECG was recorded,and mean arterial pressure and heart rate were simultaneously recorded. Tp-e interval and Tp-e/QT ratio were calculated.Results Compared with the baseline before infusion of cefuroxime sodium or cefathiamidine,Tp-e interval was significantly prolonged after completion of infusion and at 5min after propofol reached the target concentration in group CEFU,and Tp-e interval was significantly prolonged,and Tp-e/QT ratio was enlarged in group CEFA(P<0.05).There was no significant difference between the two groups in mean arterial pressure and heart rate at each time point (P>0.05).Conclusion Preoperative prophylactic infusion of cefuroxime sodium produces less ECG interference than preoperative prophylactic infusion of cefathiamidine during anesthesia induction with propofol.
